/*eoe indication subpages*/
/*Role of epithelium*/
@font-face {
  font-family: "din-condensed";
    src: url("https://use.typekit.net/af/3b5b6c/00000000000000007758da28/31/l?primer=7fa3915bdafdf03041871920a205bef951d72bf64dd4c4460fb992e3ecc3a862&fvd=n4&v=3") format("woff2"), url("https://use.typekit.net/af/3b5b6c/00000000000000007758da28/31/d?primer=7fa3915bdafdf03041871920a205bef951d72bf64dd4c4460fb992e3ecc3a862&fvd=n4&v=3") format("woff"), url("https://use.typekit.net/af/3b5b6c/00000000000000007758da28/31/a?primer=7fa3915bdafdf03041871920a205bef951d72bf64dd4c4460fb992e3ecc3a862&fvd=n4&v=3") format("opentype");
    font-display: auto;
    font-style: normal;
    font-weight: 400;
    font-stretch: normal;
}

@font-face {
  font-family: "din-condensed";
    src: url("https://use.typekit.net/af/b494eb/000000000000000077359e30/31/l?primer=7fa3915bdafdf03041871920a205bef951d72bf64dd4c4460fb992e3ecc3a862&fvd=n3&v=3") format("woff2"), url("https://use.typekit.net/af/b494eb/000000000000000077359e30/31/d?primer=7fa3915bdafdf03041871920a205bef951d72bf64dd4c4460fb992e3ecc3a862&fvd=n3&v=3") format("woff"), url("https://use.typekit.net/af/b494eb/000000000000000077359e30/31/a?primer=7fa3915bdafdf03041871920a205bef951d72bf64dd4c4460fb992e3ecc3a862&fvd=n3&v=3") format("opentype");
    font-display: auto;
    font-style: normal;
    font-weight: 300;
    font-stretch: normal;
}

body:is(#eoe-mod,#eoe-role-of-epithelium) .cmp-teaser__content {
  background: unset;
  min-height: unset;
  position: absolute;
  top: 33%;
  justify-content: center;
}

body:is(#eoe-mod,#eoe-role-of-epithelium) .teaser .cmp-teaser__image img {
  min-height: 244px;
}

body:is(#eoe-mod,#eoe-role-of-epithelium) {
  background-color: unset !important;
}

body:is(#eoe-mod,#eoe-role-of-epithelium) .teaser {
  position: relative;
}

body:is(#eoe-mod,#eoe-role-of-epithelium) .cmp-teaser__image {
  width: 100%;
  padding-right: 0;
  padding-top: 90px;
}

body:is(#eoe-mod,#eoe-role-of-epithelium) .cmp-teaser__title {
  font-size: 40px;
  line-height: 48px;
  font-family: 'din-2014', sans-serif;
  text-align: center;
  color: #fff;
  font-weight: 700;
  padding-inline: 20px;
}

#eoe-role-of-epithelium .cmp-title__text.cmp-title__text--h2 {
  font-family: din-condensed;
  font-size: 40px;
  line-height: 46px;
  font-weight: 500;
  color: #1C4758;
  text-align: center;
  max-width: 1050px;
  margin-inline: auto;
  margin-top: -9px;
  margin-bottom: 22px;
  letter-spacing: -0.9px;
}

#eoe-role-of-epithelium .cmp-title__text.cmp-title__text--h2 sup {
  font-family: 'din-condensed'!important;
  font-weight: 500!important;
}

.nowrap {
  white-space: nowrap;
}

#eoe-role-of-epithelium #section-1 h2 {
  font-size: 34px;
  text-align: center;
  line-height: 34px;
  font-family: 'din-2014', sans-serif;
  font-weight: 700;
  margin-top: 0;
}

#eoe-role-of-epithelium #section-1 h2 span {
  display: block;
  font-weight: 400;
}

#eoe-role-of-epithelium #blue-box {
  max-width: 900px;
  margin-inline: auto;
  background-color: #1D4757;
  color: #fff;
  border-radius: 20px;
  padding: 35px 44px !important;
  display: flex;
  gap: 57px;
  justify-content: space-between;
  margin-top: 15px;
  margin-bottom: 36px;
}

#eoe-role-of-epithelium #role-eoe-new-sec {
  max-width: 900px;
  margin-inline: auto;
  margin-top: 35px;
  margin-bottom: 65px;
}

#eoe-role-of-epithelium .referencebox .no-link-ios a[href^="tel:"] {
  color: inherit !important;
  text-decoration: none !important;
}

#eoe-role-of-epithelium #role-eoe-new-sec p:first-child {
  font-family: 'din-2014', sans-serif;
  font-weight: 700;
  font-size: 26px;
  line-height: 28px;
  letter-spacing: 0%;
  text-align: center;
  color: #1D4758;
  margin-bottom: 16px;
  -webkit-font-feature-settings: "liga" 0, "clig" 0;
  font-feature-settings: "liga" 0, "clig" 0;
  -webkit-font-variant-ligatures: none;
  font-variant-ligatures: none;
}

#role-eoe-new-sec p:nth-of-type(2) {
  color: #0377AD;
  font-family: 'din-2014', sans-serif;
  font-weight: 700;
  font-style: Bold;
  font-size: 26px;
  line-height: 28px;
  letter-spacing: 0%;
  text-align: center;
  /*text-transform: uppercase;*/
  ;
}

#epicascade-footer .references-all.eoe-role-of-epithelium .referencebox p {
  max-width: 1108px!important;
  -webkit-font-feature-settings: "liga" 0, "clig" 0;
  font-feature-settings: "liga" 0, "clig" 0;
  -webkit-font-variant-ligatures: none;
  font-variant-ligatures: none;
}

#eoe-role-of-epithelium .ns-explore-more-btn.airways-explore {
  display: none!important;
}

#eoe-role-of-epithelium .ns-explore-more-btn.eoe-airways-explore {
  display: block!important;
}

#eoe-role-of-epithelium .ns-explore-more-btn.eoe-mod-explore {
  display: none!important;
}

#eoe-role-of-epithelium #box-with-img .right {
  max-width: 532px;
}

#eoe-role-of-epithelium #box-with-img .right h3 {
  font-size: 26px;
  line-height: 28px;
  margin-top: 0;
  margin-bottom: 16px;
  font-family: 'din-2014', sans-serif;
}

#eoe-role-of-epithelium #box-with-img .right p {
  font-size: 26px;
  line-height: 28px;
  font-family: 'din-2014', sans-serif;
  margin-bottom: 8px;
  color: #9FD7F1;
  font-weight: 700;
}

#eoe-role-of-epithelium #box-with-img .right li {
  font-size: 20px;
  line-height: 30px;
  font-family: 'din-2014', sans-serif;
  position: relative;
  margin-left: 16px;
  -webkit-font-feature-settings: "liga" 0, "clig" 0;
  font-feature-settings: "liga" 0, "clig" 0;
  -webkit-font-variant-ligatures: none;
  font-variant-ligatures: none;
  font-weight: 400;
}

#eoe-role-of-epithelium #box-with-img .right li:before {
  content: '';
  position: absolute;
  background: #fff;
  width: 5px;
  height: 5px;
  border-radius: 10px;
  left: -16px;
  top: 50%;
}

#eoe-role-of-epithelium #section-1 .cmp-container__backgroundImage--enabled {
  background: unset !important;
  margin: unset;
}

body:is(#eoe-role-of-epithelium,#eoe-mod) #section-1 {
  padding-top: 220px;
  background-image: url("/content/dam/intelligentcontent/unbranded/epicascade/us/en/assets/update_image/global_icons/desktop/epithelium.png");
  background-repeat: no-repeat;
  background-size: contain;
  padding-top: clamp(275px, calc(275px + (100vw - 1440px) * 0.176), 410px);
  background-position: top;
  max-width: 2000px;
  margin: 0 auto;
}

#eoe-role-of-epithelium .ns-explore-more-btn.airways-explore {
  display: block;
}

#eoe-clinical-challenges .ns-explore-more-btn.eoe-challenges-explore {
  display: block;
}

#eoe-mod .next-em {
  visibility: hidden;
}

body:is(#eoe-mod,#eoe-role-of-epithelium) sup {
  font-size: 50%;
  font-family: 'din-2014';
  LINE-HEIGHT: 1;
}

#eoe-role-of-epithelium #box-with-img .right .light-txt {
  font-weight: 400;
}

#eoe-role-of-epithelium #box-with-img .right .bold-txt {
  font-weight: 600;
  font-style: italic;
  font-size: 24px;
  color: inherit;
}
/*eoe clinical-challanges starts*/

#eoe-clinical-challenges .cmp-teaser__content {
  background: unset;
  min-height: unset;
  position: absolute;
  top: 33%;
  justify-content: center;
}

#eoe-clinical-challenges .teaser .cmp-teaser__image img {
  min-height: 244px;
}

#eoe-clinical-challenges {
  background-color: unset !important;
}

#eoe-clinical-challenges .teaser {
  position: relative;
}

#eoe-clinical-challenges .cmp-teaser__image {
  width: 100%;
  padding-right: 0;
  padding-top: 90px;
}

#eoe-clinical-challenges .cmp-teaser__title {
  font-size: 40px;
  line-height: 48px;
  font-family: 'din-2014', sans-serif;
  text-align: center;
  color: #fff;
  font-weight: 700;
  padding-inline: 20px;
  margin-top: 8px;
  margin-inline: auto;
  max-width: 85%;
}

#eoe-clinical-challenges #burden-three-card {
  background: white;
  margin-top: -1px;
}

#eoe-clinical-challenges #burden-three-card .burden-container {
  display: flex;
  max-width: 1168px;
  padding: 0 24px;
  margin: 0 auto;
  gap: 34px;
  justify-content: center;
  flex-flow: row wrap;
}

#eoe-clinical-challenges #burden-three-card .burden-card .burden-card__title {
  color: #FFF;
  text-align: center;
  font-family: 'din-2014', sans-serif;
  font-size: 20px;
  font-style: normal;
  font-weight: 700;
  line-height: 28px;
  display: flex;
  padding: 9px 20px;
  justify-content: center;
  align-items: center;
  gap: 10px;
  align-self: stretch;
  background: #1D4757;
  max-width: 600px;
  margin: 0 auto;
}

.burden-card {
  flex: 0 0 31.3%;
}

#eoe-clinical-challenges #burden-three-card .burden-card__content {
  display: flex;
  padding: 48px 24px;
  flex-direction: column;
  justify-content: center;
  align-items: center;
  gap: 14px;
  border-radius: 0 0 20px 20px;
  background: #EBF4F8;
  align-self: stretch;
  max-height: 370px;
  height: 100%;
}

#eoe-clinical-challenges #burden-three-card .burden-card:last-child .burden-card__content {
  padding-top: 32px;
}

#eoe-clinical-challenges #burden-three-card h2 {
  margin: 0;
  color: #B70028;
  text-align: center;
  font-family: 'din-2014', sans-serif;
  font-size: 32px;
  font-style: normal;
  font-weight: 700;
  line-height: 36px;
}

#eoe-clinical-challenges #burden-three-card p {
  color: #333;
  text-align: center;
  font-family: 'din-2014', sans-serif;
  font-size: 16px;
  font-style: normal;
  font-weight: 400;
  line-height: 28px;
}

/*10-08-26*/
#eoe-clinical-challenges {
  background: unset !important;
}

#one-line-txt p {
  font-size: 40px;
  line-height: 40px;
  text-align: center;
  font-family: 'din-condensed',sans-serif;
  color: #1C4758;
  font-weight: 500;
  letter-spacing: -1px;
}

#eoe-clinical-challenges sup {
  font-size: 64%;
  line-height: 1;
}

#one-line-txt p sup {
  font-size: 55%;
  font-weight: 700;
  position: relative;
  top: 2px;
}

#one-line-txt {
  margin-bottom: 44px;
  padding-inline: 24px !important;
  max-width: 85%;
  margin-inline: auto;
}

#eoe-clinical-challenges #burden-three-card .burden-container {
}

#eoe-clinical-challenges #burden-three-card h3 {
  font-size: 32px;
  line-height: 36px;
  font-family: 'din-condensed',sans-serif;
  text-align: center;
  color: #1C4758;
}

#eoe-clinical-challenges #burden-three-card:after {
  content: '';
  background: #1D4757;
  width: 100%;
  height: 1px;
  position: absolute;
  max-width: 1110px;
  margin-inline: auto;
  left: 0;
  right: 0;
  bottom: -70px;
}

#eoe-clinical-challenges #despite-block h2 {
  font-size: 40px;
  line-height: 46px;
  font-family: 'din-condensed',sans-serif;
  text-align: center;
  color: #1C4758;
  font-weight: 500;
  margin-top: 135px;
  max-width: 80%;
  margin-inline: auto;
  letter-spacing: -1px;
}

#eoe-clinical-challenges .burden-card:last-child p {
  max-width: 90%;
}

#eoe-clinical-challenges .box-img-txt {
  display: flex;
  max-width: 1116px;
  margin-inline: auto;
  border-radius: 20px;
  background-color: #EBF4F8;
  overflow: hidden;
  gap: 48px;
  margin-bottom: 40px;
  margin-top: 46px;
  align-items: center;
  max-height: 300px;
}

#eoe-clinical-challenges .box-img-txt .top-txt {
  font-size: 26px;
  line-height: 28px;
  font-family: 'din-2014',sans-serif;
  color: #1D4757;
  margin-top: unset;
  text-align: center;
  margin-bottom: 12px;
}

#eoe-clinical-challenges .txt-grp {
  padding-block: 66.5px;
  padding-right: 48px;
  padding-block: 48px;
}

#eoe-clinical-challenges .pink-txt {
  color: #B70028;
}

#eoe-clinical-challenges .bottom-two-txt p span {
  font-size: 26px;
  line-height: 28px;
  font-weight: 700;
  font-family: 'din-2014',sans-serif;
}

#eoe-clinical-challenges .bottom-two-txt p {
  font-size: 20px;
  line-height: 28px;
  font-family: 'din-2014',sans-serif;
  color: #1D4757;
  font-weight: 700;
}

#eoe-clinical-challenges .bottom-two-txt p.subtxt {
  font-size: 14px;
  line-height: 16px;
  font-family: 'din-2014',sans-serif;
  color: #1D4757;
  font-weight: 400;
  margin-top: 10px;
}

.bottom-two-txt {
  justify-content: space-between;
  display: flex;
  gap: 24px;
  padding-inline: 0;
  position: relative;
  margin-top: 50px;
}

#eoe-clinical-challenges .box-img-txt .image {
  max-width: 326px;
  width: 100%;
}

#eoe-clinical-challenges .bottom-two-txt:before {
  content: '';
  position: absolute;
  top: -38px;
  width: 100%;
  height: 1px;
  background-color: #1D4757;
  left: 0px;
}

#eoe-clinical-challenges .normal-two-txt p {
  font-size: 20px;
  line-height: 30px;
  font-family: 'din-2014',sans-serif;
  color: #1D4758;
  font-weight: 400;
  margin-bottom: 12px;
}

.normal-two-txt p .pink-txt {
  font-weight: 700;
}

#eoe-clinical-challenges .box-img-txt:nth-child(2) .txt-grp {
  max-width: 100%;
}

#eoe-clinical-challenges .box-img-txt .image img {
  width: auto;
  object-fit: cover;
}

#eoe-clinical-challenges .box-img-txt:nth-child(3) {
  align-items: self-start;
}

#eoe-clinical-challenges .box-img-txt:nth-child(3) .btm-txt {
  font-size: 20px;
  line-height: 28px;
  text-transform: uppercase;
  font-family: 'din-2014',sans-serif;
  text-align: center;
  color: #1D4757;
  margin-top: 20px;
  margin-bottom: 0;
}

#eoe-clinical-challenges #despite-block .greenbox {
  font-size: 26px;
  line-height: 28px;
  text-align: center;
  font-family: 'din-2014',sans-serif;
  font-weight: 700;
  background-color: #1D4757;
  max-width: 1116px;
  margin-inline: auto;
  padding: 14.68px 43px;
  color: #fff;
  border-radius: 10px;
}

#eoe-clinical-challenges #chart-block {
  max-width: 1116px;
  margin-inline: auto;
  text-align: center;
  background-color: #EBF4F8;
  padding: 24px 37px;
  border-radius: 20px;
  width: calc(100% - 48px);
}

#eoe-clinical-challenges #chart-block-tile .cmp-title__text.cmp-title__text--h2 {
  font-size: 40px;
  line-height: 46px;
  font-family: 'din-condensed',sans-serif;
  font-weight: 500;
  color: #1C4758;
  text-align: center;
  letter-spacing: -.7px;
}

#eoe-clinical-challenges #chart-block-tile {
  position: relative;
}

#eoe-clinical-challenges #img-top-txt p {
  font-size: 20px;
  line-height: 28px;
  font-family: 'din-2014',sans-serif;
  font-weight: 700;
  color: #1D4757;
  margin-bottom: 33px;
}

#eoe-clinical-challenges #despite-block {
  position: relative;
  margin: 0 24px 140px;
}

#eoe-clinical-challenges #despite-block:after {
  content: '';
  background: #1D4757;
  width: 100%;
  height: 1px;
  position: absolute;
  max-width: 1110px;
  margin-inline: auto;
  left: 0;
  right: 0;
  bottom: -70px;
}

#eoe-clinical-challenges #centered-cta-block {
  max-width: 1116px;
  box-shadow: 0px 4px 10px 0px #00000040;
  padding: 48px;
  margin-inline: auto;
  border-radius: 20px;
  margin-top: 40px;
  margin-bottom: 80px;
  width: calc(100% - 48px);
}

#eoe-clinical-challenges #centered-cta-block h3 {
  margin-top: unset;
  font-size: 32px;
  line-height: 40px;
  text-align: center;
  color: #1D4757;
  margin-bottom: 24px;
  font-family: 'din-2014', sans-serif;
  font-weight: 700;
  max-width: 85%;
  margin-inline: auto;
}

#eoe-clinical-challenges .centered-w-icon {
  display: flex;
  align-items: center;
  gap: 10px;
  height: 80px;
  max-width: 323px;
  background-color: #1C4758;
  color: #fff;
  font-size: 20px;
  line-height: 24px;
  font-family: 'din-2014',sans-serif;
  font-weight: 800;
  text-transform: uppercase;
  border-radius: 40px;
  justify-content: center;
  padding-left: 18px;
  margin-inline: auto;
}

#eoe-clinical-challenges .centered-w-icon img {
  padding-left: 10px;
}

#eoe-clinical-challenges #reference-variable ul li {
  font-family: "Din-2014", sans-serif;
  font-weight: 500;
  text-align: left;
  font-size: 14px;
  color: #fff;
  line-height: 16px;
  padding-top: 14px;
  /*display: flex;*/
  text-indent: -5px;
  padding-left: 5px;
}

#eoe-clinical-challenges #reference-variable ul li:not(:first-child) {
  padding-top: 6px;
}

#eoe-clinical-challenges #reference-variable > ul > li:nth-child(6) {
  max-width: 99%;
}

#eoe-clinical-challenges #epicascade-footer .referencebox p .new-line {
  display: inline-block;
}

#eoe-clinical-challenges #chart-block #second-graph-img {
  width: 252px;
  margin: 0 auto;
}

#eoe-clinical-challenges #epicascade-footer .referencebox p {
  letter-spacing: -0.256px;
}

#eoe-clinical-challenges #reference-variable ul li .first-sup {
  position: relative;
  top: 1px;
}

#eoe-clinical-challenges #epicascade-footer #reference-variable p {
  padding-top: unset;
  font-weight: 500;
  margin-left: 0px !important;
  line-height: 24px;
  padding-bottom: 7px;
}

#eoe-clinical-challenges #reference-variable ul {
  margin-top: 45px;
  margin-bottom: 10px;
}

/*end*/


/*#eoe-clinical-challenges*/
/*#eoe-clinical-challenges*/
/*#eoe-clinical-challenges*/

/*Mod CSS*/
#eoe-mod #top-txt h2 {
  font-size: 48px;
  line-height: 100%;
  font-weight: 500;
  text-align: center;
  font-family: din-condensed,sans-serif;
  color: #1D4758;
  margin-bottom: 27px;
  padding-inline: 24px;
  letter-spacing: -0.9px;
  margin-top: 0;
}

#eoe-mod .txt-w-cta h3 span .blue-text {
  color: #1D4758;
}

#eoe-mod #top-txt h3 {
  font-size: 32px;
  line-height: 28px;
  text-align: center;
  font-family: 'din-2014',sans-serif;
  color: #1D4757;
  padding-inline: 24px;
  margin-bottom: 18px;
  font-weight: 400;
}

#eoe-mod #section-1 h2 {
  font-family: 'din-2014', sans-serif;
  font-size: 32px;
  /*line-height: 28px;*/
  line-height: 36px;
  text-align: center;
  color: #1D4757;
  max-width: 65%;
  margin-inline: auto;
  margin-top: -5px;
  margin-bottom: 4px;
  font-weight: 400;
}

#eoe-mod #section-1 .image {
  margin-inline: auto;
  text-align: center;
  float: unset;
  max-width: 700px;
  padding-inline: 24px;
  margin-bottom: 48px;
}

#eoe-mod h1.cmp-teaser__title sup {
  white-space: nowrap;
}

.bold {
  font-weight: 700;
}

#eoe-mod #section-1 .image:nth-child(4) img {
  padding-top: 6px;
}

#eoe-mod #bottom-txt h2 {
  font-size: 32px;
  line-height: 28px;
  text-align: center;
  font-family: 'din-2014',sans-serif;
  color: #1D4757;
  margin-block: 0 30px;
  margin: 0 auto;
  margin-block: 0 30px;
  margin-top: 5px;
  width: 80%;
  font-weight: 400;
}

#eoe-mod #bottom-txt {
  margin-top: -4px;
}

#eoe-mod #bottom-txt .blue-r-box, #eoe-mod #top-txt-detail .blue-r-box {
  font-family: 'din-condensed',sans-serif;
  font-weight: 500;
  max-width: 327px;
  border-radius: 12px;
  background-color: #0377AD;
  text-align: center;
  color: #fff;
  padding-block: 7px 6px;
  font-size: 30px;
  line-height: 21px;
  margin-inline: auto;
  margin-bottom: 22px;
  height: 40px;
  text-transform: uppercase;
}

#eoe-mod #top-txt-detail .blue-r-box {
  max-width: fit-content !important;
  padding: 10px 40px;
  margin-bottom: 25px;
}

#eoe-mod #top-txt-detail .trigger-section .blue-r-box {
  position: relative;
}

#eoe-mod #top-txt-detail .trigger-section .blue-r-box::before,
#eoe-mod #top-txt-detail .trigger-section .blue-r-box::after {
  content: "";
  position: absolute;
  top: 50%;
  width: 300px;
  height: 1px;
  background: #000;
}

#eoe-mod #top-txt-detail .trigger-section .blue-r-box::before {
  right: 100%;
  margin-right: 10px;
}

#eoe-mod #top-txt-detail .trigger-section .blue-r-box::after {
  left: 100%;
  margin-left: 10px;
}

#eoe-mod #top-txt-detail .trigger-options {
  display: flex;
  justify-content: center;
  gap: 150px;
}

#eoe-mod #top-txt-detail .trigger-options span {
  color: #262626;
  font-family: 'din-2014', sans-serif;
  font-size: 24px;
  /*font-weight: 600;*/
  font-weight: 400;
  line-height: normal;
}

#eoe-mod #top-txt-detail .trigger-section {
  margin-top: 24px;
  margin-bottom: 10px;
}

#mod-first-img > img.cmp-image__image.cmp-image--desktop {
  margin-block: 5px;
}

#eoe-mod #bottom-txt .four-pink .pink {
  font-size: 30px;
  line-height: 1;
  font-family: 'din-condensed',sans-serif;
  font-weight: 500;
  padding: 15px 46px;
  background-color: #8A49B4;
  color: #fff;
  border-radius: 12px;
  min-width: 260px;
  text-align: center;
  text-transform: uppercase;
}

#eoe-mod #bottom-txt .four-pink {
  display: flex;
  justify-content: center;
  gap: 24px;
  flex-flow: row wrap;
  margin-bottom: 80px;
}

#eoe-mod #bottom-txt .green-box {
  background-color: #1D4757;
  text-align: center;
  font-size: 20px;
  line-height: 28px;
  font-family: 'din-2014',sans-serif;
  color: #fff;
  padding-block: 15px;
  max-width: 1116px;
  border-radius: 12px;
  margin-inline: auto;
  display: none;
}

#eoe-mod #Thank-you-box {
  box-shadow: 0px 4px 10px 0px #00000040;
  max-width: 1110px;
  border-radius: 20px;
  margin-inline: auto;
  padding: 58px !important;
  margin-block: 80px;
}

#eoe-mod .txt-w-cta {
  display: flex;
  gap: 154px;
}

#eoe-mod .txt-w-cta h3 {
  margin: unset;
  font-size: 34px;
  line-height: 1;
  text-align: right;
  font-family: 'din-2014',sans-serif;
  max-width: 467px;
  text-transform: uppercase;
}

#eoe-mod #Thank-you-box .txt-w-cta h3 {
  color: #1D4758;
}

#eoe-mod .txt-w-cta h3 span {
  color: #B70028;
}

#eoe-mod  .ns-explore-more-btn.eoe-mod-explore {
  display: block !important;
}

#eoe-mod .cta-w-icon {
  display: flex;
  align-items: center;
  min-width: 277px;
  justify-content: center;
  gap: 7.24px;
  font-size: 20px;
  line-height: 24px;
  color: #fff;
  font-weight: 700;
  font-family: 'din-2014-narrow',sans-serif;
  text-transform: uppercase;
  height: 78px;
  border: 3px solid transparent;
  border-radius: 40px;
  background: linear-gradient(#650E26, #650E26) padding-box,
    linear-gradient(90deg, #B70028 0%, #0092CA 100%) border-box;
}

#eoe-mod .cta-w-icon span {
  height: 26px;
}

#eoe-mod #epicascade-footer .referencebox p {
  max-width: 1100px;
}

#eoe-mod #epicascade-footer .referencetext p {
  font-size: 16px;
}

#eoe-mod .eoe-mod-explore .explore-more-txt {
  color: #fff;
  font-weight: 700;
}

#eoe-mod #section-1 .image {
  margin-bottom: 0 !important;
}

#eoe-mod #section-1 #mod-first-img {
  margin-bottom: 25px;
}

#eoe-mod #section-1 #mod-second-img {
  margin-bottom: 18px;
}

#epicascade-footer #epi-footer-top .referencebox b {
  font-weight: 700;
}

@media(min-width:992px) {
  #eoe-clinical-challenges #burden-three-card .burden-card__content {
    padding-top: 30px;
    padding-bottom: 38px;
    max-height: 378px;
    justify-content: start;
    gap: unset;
  }

  #eoe-role-of-epithelium .cmp-title__text.cmp-title__text--h2 {
    padding-inline: 20px;
  }

  #text-40a4c329ec > div:nth-child(3) > div.txt-grp {
    padding-block: 84px;
  }

  #eoe-clinical-challenges .bottom-two-txt p.subtxt {
    text-indent: -4px;
    width: 90%;
  }

  #heading-mtop > h2 {
    max-width: 54% !important;
  }

  #eoe-clinical-challenges #burden-three-card h2 {
    max-width: 90%;
    margin-top: 25px;
    margin-bottom: 10px;
  }

  body:is(#eoe-mod,#eoe-role-of-epithelium) .cmp-teaser__title {
    padding-left: 5%;
  }

  #eoe-mod #top-txt h2 {
    padding-left: 3%;
  }

  #eoe-mod #bottom-txt .blue-r-box {
    padding-block: 10px 6px;
  }

  #eoe-mod #section-1 #cytokine-heading h2 {
           /*max-width: 39%;*/
    max-width: unset;
               /*text-align: end;*/;
  }

  #eoe-mod  #section-1 #cytokine-heading h2 span.nowrap-xl {
    white-space: nowrap;
  }

  #eoe-mod #quiz-container {
    margin-inline: 20px;
  }
}
/*desktop end*/
/*Mobile start */
@media(max-width:991.5px) {
    
  #eoe-clinical-challenges .bottom-two-txt p.subtxt {
    text-align: left;
    text-indent: -4px;
    padding-bottom: 15px;
  }

  .normal-two-txt {
    width: 80%;
    margin: 0 auto;
  }
  .cmp-teaser .cmp-teaser__image-mobile .cmp-image__image {
    height: revert-layer;
  }

  body:is(#eoe-mod,#eoe-role-of-epithelium) .cmp-teaser__content {
    top: 50%;
  }

 
  #eoe-clinical-challenges #burden-three-card .burden-card:last-child .burden-card__content {
    padding-top: 45px;
  }

  #eoe-clinical-challenges #burden-three-card .burden-card__content {
    padding-block: 45px;
    max-height: unset;
    max-width: 600px;
    margin: 0 auto;
  }

  #burden-three-card > div > div:nth-child(3) > div.burden-card__content > p {
    padding: 0 18px;
  }

  body:is(#eoe-mod,#eoe-role-of-epithelium) .cmp-teaser__image-mobile {
    display: block;
  }

  body:is(#eoe-mod,#eoe-role-of-epithelium)  .cmp-teaser__image-desktop {
    display: none;
  }

  body:is(#eoe-mod,#eoe-role-of-epithelium) .cmp-teaser__title {
    font-size: 24px;
    line-height: 1;
    padding-top: unset;
  }

  body:is(#eoe-mod,#eoe-role-of-epithelium) .cmp-teaser__content {
    /*min-height: clamp(18.5rem, 9.02vw + 16.3rem, 20.63rem);*/
    display: flex;
    align-items: center;
  }

  #eoe-role-of-epithelium .cmp-title__text.cmp-title__text--h2 {
    font-size: 32px;
    line-height: 36px;
    margin-top: 2px;
    padding-inline: 20px;
    margin-bottom: 17px;
  }

  body:is(#eoe-role-of-epithelium,#eoe-mod) #section-1 {
    background-size: 115%;
    background-position: top;
    padding-top: clamp(105px, calc(105px + (100vw - 390px) * 0.35), 300px);
    padding-inline: 24px;
  }

  #eoe-role-of-epithelium #section-1 h2 {
    font-size: 28px;
    line-height: 32px;
  }

  #eoe-role-of-epithelium #section-1 h2 span {
    display: inline;
    margin-left: 4px;
  }

  #eoe-role-of-epithelium #blue-box {
    flex-direction: column;
    gap: 16px;
    padding: 16px 16px 20px 16px !important;
    margin-bottom: 32px;
    max-width: 600px;
  }

  #eoe-role-of-epithelium #box-with-img .right h3 {
    font-size: 20px;
    line-height: 24px;
  }

  #eoe-role-of-epithelium #role-eoe-new-sec p:first-child {
    font-family: 'din-2014', sans-serif;
    font-weight: 700;
    font-style: Bold;
    font-size: 20px;
    leading-trim: NONE;
    line-height: 30px;
    letter-spacing: 0%;
    text-align: center;
    margin-bottom: 15px;
  }

  #role-eoe-new-sec p:nth-of-type(2) {
    font-family: 'din-2014', sans-serif;
    font-weight: 700;
    font-style: Bold;
    font-size: 20px;
    leading-trim: NONE;
    line-height: 24px;
    letter-spacing: -0.1px;
    text-align: center;
    /*text-transform: uppercase;*/
    ;
  }

  #eoe-role-of-epithelium #role-eoe-new-sec {
    margin-bottom: 30px;
    margin-top: 30px;
  }

  #eoe-role-of-epithelium #box-with-img .right p,#eoe-role-of-epithelium #box-with-img .right .bold-txt {
    font-size: 20px;
    line-height: 24px;
    Font-weight: 700;
    max-width: 91%;
  }

  #eoe-role-of-epithelium #box-with-img .right li {
    font-weight: 400;
    font-size: 16px;
    line-height: 30px;
  }

  #eoe-role-of-epithelium #box-with-img .right ul {
    margin-left: 3px;
  }

  body:is(#eoe-mod,#eoe-role-of-epithelium) .teaser .cmp-teaser__image img {
    top: unset;
  }

  #eoe-role-of-epithelium #blue-box .m-hide {
    display: none;
  }

  #eoe-role-of-epithelium #blue-box .m-visible {
    display: block;
    width: 100%;
  }

  body:is(#eoe-mod,#eoe-role-of-epithelium) .cmp-teaser__image {
    padding-top: unset;
  }

/*Clinical mobile view CSS*/
  #eoe-clinical-challenges .box-img-txt .image .mobile-hide {
    display: none;
  }

  #eoe-clinical-challenges .box-img-txt .image .mobile-show {
    display: block;
  }

  #eoe-clinical-challenges .cmp-teaser__title {
    font-size: 24px;
    line-height: 24px;
    max-width: 100%;
    margin-top: 6px;
  }

  #eoe-clinical-challenges .cmp-teaser__image {
    padding-top: 0;
  }

  #eoe-clinical-challenges .cmp-teaser__content {
    top: 53%;
  }

  #eoe-clinical-challenges #reference-variable ul {
    margin-top: 25px;
  }

  #eoe-clinical-challenges #epicascade-footer #reference-variable p {
    line-height: 16px;
    margin-left: unset !important;
  }

  #eoe-clinical-challenges #reference-variable ul li .first-sup {
    /*top: 5px;*/
  }

  #eoe-clinical-challenges #reference-variable ul li {
    max-width: 99%;
  }

  #eoe-clinical-challenges #epicascade-footer .referencebox p {
    letter-spacing: unset;
    max-width: 99.75%;
  }

  #eoe-clinical-challenges #epicascade-footer .referencebox p a {
    color: inherit;
  }

  #eoe-clinical-challenges #reference-variable ul li:nth-child(6) {
    letter-spacing: -0.05px;
  }

  #one-line-txt p {
    font-size: 32px;
    line-height: 36px;
  }

  #one-line-txt {
    margin-bottom: 35px;
    margin-top: 10px;
    max-width: 100%;
  }

  #eoe-clinical-challenges #burden-three-card .burden-container {
    flex-direction: column;
    gap: 33px;
  }

  #eoe-clinical-challenges #burden-three-card h2 {
    min-height: auto;
    margin-bottom: 6px;
  }

  #eoe-clinical-challenges #burden-three-card h2 br {
    display: none;
  }

  #eoe-clinical-challenges #burden-three-card p {
    letter-spacing: -0.5px;
  }

  #eoe-clinical-challenges #burden-three-card h3 {
    padding-inline: 24px;
  }

  #eoe-clinical-challenges #chart-block-tile .cmp-title__text.cmp-title__text--h2 {
    font-size: 32px;
    line-height: 36px;
    padding-inline: 24px;
    margin-top: 80px;
    margin-bottom: 30px;
    letter-spacing: unset;
  }

  #eoe-clinical-challenges #burden-three-card:after {
    bottom: -37px;
     width: 87.75%;
  }

  #eoe-clinical-challenges #chart-block {
    padding: 24px 10px;
    max-width: 600px;
  }

  #eoe-clinical-challenges #img-top-txt p {
    margin-bottom: 23px;
    ;
  }

  #eoe-clinical-challenges .box-img-txt {
    max-height: unset;
    flex-direction: column;
    margin-inline: 24px;
    margin-top: unset;
    gap: 30px;
    max-width: 600px;
    margin: 0 auto 36px;
  }

  #eoe-clinical-challenges .box-img-txt .image {
    max-width: 100%;
    width: 100%;
    height: 100%;
  }

  #eoe-clinical-challenges .box-img-txt .image img {
    width: 100%;
  }

  #eoe-clinical-challenges .txt-grp {
    /*padding-inline: 48px;*/
    padding-inline: 20px;
    padding-block: unset;
    padding-bottom: 30px;
  }

  #eoe-clinical-challenges .box-img-txt .top-txt {
    font-size: 20px;
    line-height: 28px;
  }

  #eoe-clinical-challenges .bottom-two-txt {
    margin-top: 49px;
    padding: unset;
    flex-direction: column;
    text-align: center;
    gap: 3px;
    padding-inline: 4px;
  }

  #eoe-clinical-challenges .bottom-two-txt p span {
    font-size: 20px;
    line-height: 28px;
  }

  #eoe-clinical-challenges .bottom-two-txt p {
    font-size: 16px;
    line-height: 20px;
  }

  #eoe-clinical-challenges .bottom-two-txt:before {
    top: -24px;
  }

  #eoe-clinical-challenges .normal-two-txt p {
    font-size: 16px;
    line-height: 20px;
    text-align: center;
  }

  #eoe-clinical-challenges .box-img-txt:nth-child(3) .btm-txt {
    font-size: 16px;
    line-height: 20px;
    margin-top: 27px;
  }

  #eoe-clinical-challenges #despite-block .greenbox {
    font-size: 20px;
    line-height: 28px;
    padding: 24px 10px;
    max-width: 600px;
  }

  #eoe-clinical-challenges #centered-cta-block {
    padding: 24px 9.5px;
    margin-bottom: 40px;
    margin-top: 30px;
  }

  #eoe-clinical-challenges #centered-cta-block h3 {
    font-size: 24px;
    line-height: 28px;
    max-width: 90%;
    margin-inline: auto;
  }

/*#eoe-clinical-challenges .therapi-grp {*/
/*    flex-direction: column;*/
/*    gap: 45px;*/
/*    margin-bottom: 28px;*/
/*}*/

/*#eoe-clinical-challenges .therapi-grp:before {*/
/*    width: 100%;*/
/*    height: 1px;*/
/*    left: 0;*/
/*    top: 47px;*/
/*}*/
  #eoe-clinical-challenges #despite-block h2 {
    margin-top: 80px;
    font-size: 32px;
    line-height: 36px;
    padding-inline: 6px;
    margin-bottom: 36px;
    max-width: 100%;
  }

/*#eoe-clinical-challenges .light-border-box {*/
/*    padding-inline: unset;*/
/*    padding-top: 24px;*/
/*    padding-bottom: 145px;*/
/*}*/

/*#eoe-clinical-challenges .therapi-grp .therapi-txt {*/
/*}*/

/*#eoe-clinical-challenges .therapi-w-img {*/
/*    flex-direction: column;*/
/*    padding-inline: 6px;*/
/*}*/

/*#eoe-clinical-challenges .therapi-w-img p {*/
/*    font-size: 20px;*/
/*    text-align: center;*/
/*}*/

/*#eoe-clinical-challenges .light-border-box:after {*/
/*    min-height: 142px;*/
/*    border-top-right-radius: unset;*/
/*    border-top-left-radius: unset;*/
/*}*/

/*#eoe-clinical-challenges .dark-box {*/
/*    padding: 25px 23.5px;*/
/*}*/

/*#eoe-clinical-challenges .box-w-g {*/
/*    flex-direction: column;*/
/*    align-items: center;*/
/*}*/

/*#eoe-clinical-challenges .box-w-g {*/
/*    align-items: flex-start;*/
/*    gap: 24px;*/
/*}*/

/*#eoe-clinical-challenges .box-w-txt .per-txt {*/
/*    font-size: 20px;*/
/*    line-height: 24px;*/
/*    padding-bottom: 2px;*/
/*}*/

/*#eoe-clinical-challenges .box-w-txt p {*/
/*    max-width: unset !important;*/
/*}*/

  #eoe-clinical-challenges #despite-block {
    margin-bottom: unset;
    margin: 0 24px;
  }

  #eoe-clinical-challenges #despite-block:after {
    bottom: -44px;
    /*width: calc(100% - 48px);*/
    width:100%;
  }

  #eoe-clinical-challenges .cmp-teaser__image-desktop {
    display: none;
  }

  #eoe-clinical-challenges .cmp-teaser__image-mobile {
    display: block;
  }
/*end*/

/*MOD mobile css*/
  #eoe-mod #top-txt h2 {
    font-size: 32px;
    line-height: 36px;
    margin-bottom: 15px;
    margin-top: 4px;
  }

  #eoe-mod #top-txt h3 {
    font-size: 20px;
    line-height: 24px;
    margin-top: 14px;
  }

  #eoe-mod #section-1 h2 {
    font-size: 20px;
    line-height: 24px;
    max-width: 97%;
    margin-bottom: 2px;
  }

  #eoe-mod #section-1 #cytokine-heading h2 span {
    display: inline-block;
  }

  #eoe-mod #section-1 .image:nth-child(4) img {
    padding-top: 16px;
  }

  #eoe-mod #section-1 .image {
    margin-bottom: 15px;
    padding-inline: unset;
  }

  #eoe-mod #bottom-txt .four-pink {
    flex-direction: column;
    gap: 8px;
    margin-bottom: 36px;
  }

  #eoe-mod #bottom-txt h2 {
    font-size: 20px;
    line-height: 24px;
    margin-top: 7px;
  }

  #eoe-mod #bottom-txt .blue-r-box, #eoe-mod #top-txt-detail .blue-r-box {
    font-size: 20px;
    line-height: 26px;
    max-width: 205px;
    padding-bottom: 5px;
    border-radius: 6px;
  }

  #eoe-mod #bottom-txt .four-pink .pink {
    max-width: 69.24%;
    margin-inline: auto;
    font-size: 20px;
    line-height: 1;
    width: 100%;
  }

  #eoe-mod #bottom-txt .green-box {
    max-width: 92.33%;
    font-size: 20px;
    line-height: 28px;
    padding-inline: 40px;
  }

  #eoe-mod #Thank-you-box {
    margin-block: 36px 40px;
    width: calc(100% - 48px);
    padding: 19px 43px 29px 43px !important;
  }

  #eoe-mod .txt-w-cta {
    flex-direction: column;
    align-items: center;
    gap: 11px;
  }

  #eoe-mod .txt-w-cta h3 {
    font-size: 20px;
    line-height: 24px;
    text-align: center;
  }

  #eoe-mod .cta-w-icon {
    min-width: 150px;
    height: 36px;
    font-size: 16px;
    line-height: 23px;
    max-width: 150px;
    margin-inline: auto;
  }

  #eoe-mod .cta-w-icon span {
    height: auto;
    width: 11px;
  }

  #eoe-mod #section-1 #heading-mtop {
    margin-top: 35px;
  }

  #eoe-mod #section-1 #mod-first-img {
    margin-bottom: 0;
    margin-top: 60px;
  }

  #eoe-mod #section-1 #mod-second-img {
    margin-bottom: 20px;
  }

  #eoe-mod #epicascade-footer .referencebox p {
    line-height: 26px;
  }

  #eoe-mod #top-txt-detail .trigger-section {
    padding-left: 20px;
    padding-right: 20px;
  }

  #eoe-mod #top-txt-detail .blue-r-box {
    max-width: fit-content;
    padding: 8px 20px;
    margin-bottom: 16px !important;
  }

  #eoe-mod #top-txt-detail .trigger-section .blue-r-box::before, #eoe-mod #top-txt-detail .trigger-section .blue-r-box::after {
    width: 114px !important;
  }

  #eoe-mod #top-txt-detail .trigger-options {
    gap: 60px !important;
  }

  #eoe-mod #top-txt-detail .trigger-section {
    margin-top: 16px !important;
    margin-bottom: 16px !important;
  }

  #eoe-mod #top-txt-detail .trigger-options span {
    font-size: 16px !important;
  }

  #eoe-mod #epicascade-footer .referencetext p {
    font-size: 28.55px !important;
  }

  #eoe-mod #epicascade-footer #foot-references {
    width: 85%;
  }

  #eoe-mod #epicascade-footer #reference-variable p {
    padding-right: 0;
  }

  #eoe-mod #bottom-txt h2 {
    margin-bottom: 16px !important;
  }
@supports (-webkit-touch-callout: none) {
   
  #epicascade-footer .references-all .referencebox p a{
    color: inherit !important;
    -webkit-text-fill-color: inherit !important;
    text-decoration: none !important;
    pointer-events: none !important;
     cursor: default;
}


  #epicascade-footer .references-all .referencebox p, 
#epicascade-footer .references-all .referencebox {
    -webkit-touch-callout: none;
  }
}
/*Mobile end*/
}

#burden-three-card > div > div:nth-child(1) > div.burden-card__content > p > span {
  top: -3px;
  position: relative;
}

@media screen and (min-width: 0px) and (max-width: 389px) {
  #eoe-clinical-challenges .cmp-teaser__content {
    top: 43%;
  }

  body:is(#eoe-mod) .teaser .cmp-teaser__image img {
    min-height: 290px;
  }

  #eoe-mod #top-txt-detail .trigger-section .blue-r-box::before, 
#eoe-mod #top-txt-detail .trigger-section .blue-r-box::after {
    width: 85px !important;
  }

  #eoe-clinical-challenges .teaser .cmp-teaser__image img {
    min-height: 347px;
  }

  #eoe-role-of-epithelium .teaser .cmp-teaser__image img {
    min-height: 275px !important;
  }

  #eoe-clinical-challenges .centered-w-icon img {
    margin-right: 15px;
  }

  #eoe-role-of-epithelium #box-with-img .right p, #eoe-role-of-epithelium #box-with-img .right .bold-txt {
    max-width: 95% !important;
  }

  #eoe-role-of-epithelium #box-with-img .right li {
    font-size: 15px !important;
  }
}

@media screen and (min-width: 992px) and (max-width: 1200px) {
  #eoe-clinical-challenges .cmp-teaser__content {
    top: 29%;
  }

  #eoe-clinical-challenges .teaser .cmp-teaser__image img {
    min-height: 337px;
  }

  #eoe-clinical-challenges #chart-block-tile .cmp-title__text.cmp-title__text--h2 {
    padding-inline: 20px;
    letter-spacing: normal;
  }

  #foot-references > div.references-all.eoe-role-of-epithelium > div.referencebox > p > br {
    display: none;
  }
}

@media only screen and (max-width: 767px) {
  #eoe-role-of-epithelium .cmp-teaser__image-mobile .cmp-image__image {
    height: 297px!important;
  }
}